Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977;6(2-3):233-40.
doi: 10.1007/BF02097764.

Tri-O-tolyl phosphate neurotoxicity: lack of evidence for autoimmunologic involvement

P G Watanabe, R P Sharma

Tri-O-tolyl phosphate neurotoxicity: lack of evidence for autoimmunologic involvement

P G Watanabe et al. Arch Environ Contam Toxicol. 1977.

Abstract

Studies on the involvement of autoimmunity in the pathogenesis of tri-O-tolyl phosphate (TOTP) induced neurotoxicity in chickens were conducted. Immunosuppressive therapy including gamma-radiation and drug treatments was utilized to determine its effects on the neurotoxic syndrome. Whole-body gamma-irradiation up to 1020 roentgens failed to show any consistent protection from the TOTP induced paralysis. Therapy involving prednisone alone or in combination with 6-mercaptopurine and antilymphocyte serum likewise indicated no protection. Stimulation of humoral and cellular immunity by TOTP was investigated. Complement fixation, precipitation tests, splenic migration inhibition, and skin tests did not indicate stimulation of autoimmunity toward nervous tissue or liver. The present investigation was unable to demonstrate primary involvement of an autoimmune nature in the neurotoxicity produced by TOTP in the chicken.

PubMed Disclaimer

References

    1. Biochem Pharmacol. 1963 Dec;12:1377-86 - PubMed
    1. Poult Sci. 1971 Sep;50(5):1503-5 - PubMed
    1. Br J Pharmacol Chemother. 1953 Jun;8(2):212-6 - PubMed
    1. Int Arch Allergy Appl Immunol. 1963;23:188-206 - PubMed
    1. Nature. 1960 Jul 23;187:327 - PubMed