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. 1997;75(2):283-6.
doi: 10.1038/bjc.1997.46.

Correlation between clinical response to interleukin 2 and HLA phenotypes in patients with metastatic renal cell carcinoma

C Bain  1 , Y Merrouche, I Puisieux, J Y Blay, S Negrier, V Bonadona, C Lasset, F Lanier, A Duc, L Gebuhrer, T Philip, M C Favrot
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Free PMC article

Correlation between clinical response to interleukin 2 and HLA phenotypes in patients with metastatic renal cell carcinoma

C Bain et al. Br J Cancer. 1997.
Free PMC article

Abstract

HLA phenotypes were characterized for 79 patients with metastatic renal cell carcinoma treated with interleukin 2 (IL-2). HLA-A32 was associated with a clinical response (P = 0.025). The frequency of HLA-A3 and/or A32 was higher among responders than non-responders (P = 0.008). Thus, these results suggest that, in vivo, IL-2 may enhance cellular-mediated immunity against a tumour antigen and that some MHC molecules are more efficient than others for endogenous tumour antigen presentation.

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