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Clinical Trial
. 1997;75(2):306-9.
doi: 10.1038/bjc.1997.50.

CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer

M Fukuoka  1 , N Masuda, S Negoro, K Matsui, T Yana, S Kudoh, Y Kusunoki, M Takada, M Kawahara, M Ogawara, N Kodama, K Kubota, K Furuse
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Free PMC article
Clinical Trial

CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer

M Fukuoka et al. Br J Cancer. 1997.
Free PMC article

Abstract

Sixty-three patients with extensive-stage small-cell lung cancer were randomized to receive either cyclophosphamide, vincristine, doxorubicin and etoposide (CODE) alone or CODE plus recombinant human granulocyte colony-stimulating factor (rhG-CSF). rhG-CSF administration in support of CODE chemotherapy resulted in increased mean total received dose intensity for all drugs (P = 0.03) with a significant improvement in survival (P = 0.004).

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