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. 1997 Feb 7;275(5301):838-41.
doi: 10.1126/science.275.5301.838.

Dopaminergic neurons protected from degeneration by GDNF gene therapy

D L Choi-Lundberg  1 , Q Lin, Y N Chang, Y L Chiang, C M Hay, H Mohajeri, B L Davidson, M C Bohn
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Dopaminergic neurons protected from degeneration by GDNF gene therapy

D L Choi-Lundberg et al. Science. .

Abstract

Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6-hydroxydopamine (6-OHDA) injected into the striatum. Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.

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  • Experiments in a Parkinson's rat model.
    Pallini R, Consales A, Lauretti L, Fernandez E. Pallini R, et al. Science. 1997 Jul 18;277(5324):389-90. doi: 10.1126/science.277.5324.389. Science. 1997. PMID: 9518368 No abstract available.

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