doi: 10.1016/0022-510x(79)90058-3.
The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs
- PMID: 90129
- DOI: 10.1016/0022-510x(79)90058-3
Item in Clipboard
The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs
J Neurol Sci.
1979 Jul.
Abstract
Cop 1, a synthetic polypeptide, was evaluated for its effect on a chronic relapsing form of experimental allergic encephalomyelitis (EAE). Pretreatment of juvenile Strain 13 guinea pigs with Cop 1 in incomplete Freund's adjuvant (IFA) which were subsequently challenged with guinea pig spinal cord in complete Freund's adjuvant (CFA) had a marked effect in delaying or preventing the appearance of clinical signs of EAE. Administration of Cop 1 on appearance of clinical signs of EAE prevented progression of the first episode of the disease. Although relapses were not always prevented, they were modified on their duration and intensity both clinically and histologically.
Similar articles
-
Participation of encephalitogen in incomplete Freund's adjuvant in the induction of experimental allergic encephalomyelitis in Hartley guinea pigs.J Neuroimmunol. 1984 Jun;6(3):187-96. doi: 10.1016/0165-5728(84)90005-5. J Neuroimmunol. 1984. PMID: 6202714
-
Suppression and reversal of allergic encephalomyelitis in rhesus monkeys with basic protein and peptides.Neurochem Res. 1979 Apr;4(2):249-58. doi: 10.1007/BF00964148. Neurochem Res. 1979. PMID: 88679
-
Suppression of acute and chronic experimental allergic encephalomyelitis in Strain 13 guinea pigs. A clinical and pathological study.J Neurol Sci. 1977 Apr;31(3):355-67. doi: 10.1016/0022-510x(77)90214-3. J Neurol Sci. 1977. PMID: 845617
-
AN ANALYSIS OF COMPONENTS OF FREUND'S ADJUVANTS IN THE PRODUCTION OF EXPERIMENTAL "ALLERGIC" ENCEPHALOMYELITIS IN THE GUINEA PIG.Z Immunitats Allergieforsch. 1964 Mar;126:193-208. Z Immunitats Allergieforsch. 1964. PMID: 14185397 Review. No abstract available.
-
Complete Freund's adjuvant as a confounding factor in multiple sclerosis research.Front Immunol. 2024 Feb 15;15:1353865. doi: 10.3389/fimmu.2024.1353865. eCollection 2024. Front Immunol. 2024. PMID: 38426111 Free PMC article. Review.
Cited by
-
Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis.J Clin Invest. 2002 Mar;109(5):641-9. doi: 10.1172/JCI14380. J Clin Invest. 2002. PMID: 11877472 Free PMC article.
-
Translational research in neurology and neuroscience 2010: multiple sclerosis.Arch Neurol. 2010 Nov;67(11):1307-15. doi: 10.1001/archneurol.2010.158. Epub 2010 Jul 12. Arch Neurol. 2010. PMID: 20625066 Free PMC article. Review.
-
Experimental autoimmune encephalomyelitis from a tissue energy perspective.F1000Res. 2017 Nov 8;6:1973. doi: 10.12688/f1000research.11839.1. eCollection 2017. F1000Res. 2017. PMID: 29167741 Free PMC article. Review.
-
Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation.Cells. 2022 May 7;11(9):1578. doi: 10.3390/cells11091578. Cells. 2022. PMID: 35563884 Free PMC article.
-
Relapsing experimental allergic encephalomyelitis. An autoimmune model of multiple sclerosis.Springer Semin Immunopathol. 1985;8(3):197-208. doi: 10.1007/BF00197296. Springer Semin Immunopathol. 1985. PMID: 3931271 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
