Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1996;103(10):1221-9.
doi: 10.1007/BF01271207.

Additive effects, but no synergistic interaction of stressful life-events and genetic loading in affective disorders

J Fritze  1 , B Schneider, K Maurer
Affiliations
Review

Additive effects, but no synergistic interaction of stressful life-events and genetic loading in affective disorders

J Fritze et al. J Neural Transm (Vienna). 1996.

Abstract

Life-event research as well as neurobiological findings point to the relevance of adverse stress for the pathogenesis of affective disorders. The well established genetic root might be related to the sensitivity to stress. In concordance, recent studies showed a synergistic interaction between genetic loading and life-events concerning the precipitation of depression, i.e. there might exist a genetic sensitization to the adverse effects of stressors. The present investigation, using information extracted from 877 case records, did not reveal a synergistic interaction concerning the age at onset and the mean frequency and duration of episodes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Psychosom Med. 1993 May-Jun;55(3):248-59 - PubMed
    1. J Neural Transm. 1987;70(3-4):295-312 - PubMed
    1. Am J Psychiatry. 1995 Jun;152(6):833-42 - PubMed
    1. Br J Psychiatry. 1985 Jul;147:5-15 - PubMed
    1. Acta Psychiatr Scand. 1992 Jan;85(1):35-8 - PubMed

MeSH terms