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. 1996 Sep;40(4):221-2.

Interferon-omega suppresses hepatitis B surface antigen production in human hepatoma cell line

V Hajnická  1 , N Fuchsberger, H Liptáková, D Stancek, P Kontsek
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  • PMID: 9014013

Interferon-omega suppresses hepatitis B surface antigen production in human hepatoma cell line

V Hajnická et al. Acta Virol. 1996 Sep.

Abstract

Biological activities of human interferon (IFN) omega are less well characterized than those of other type I human IFNs. We compared the ability of recombinant IFN-omega, IFN-alpha 2 and IFN-gamma to inhibit the production of viral hepatitis B surface antigen (HBsAg) in the human hepatoma cell line PLC/PRF/5. The results demonstrated that the capacity of IFN-omega to suppress the HBsAg synthesis was similar to that of IFN-alpha 2. The kinetics of the inhibitory effect of IFN-gamma differed from those of the two other IFNs.

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