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Review
. 1997 Jan;77(1):1-20.
doi: 10.1152/physrev.1997.77.1.1.

Cellular and molecular neuroscience of alcoholism

I Diamond  1 , A S Gordon
Affiliations
Review

Cellular and molecular neuroscience of alcoholism

I Diamond et al. Physiol Rev. 1997 Jan.

Abstract

Recent advances in neuroscience have made it possible to investigate the pathophysiology of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long-term changes in gene expression. Such changes in the brain probably underlie many of the acute and chronic neurological events in alcoholism. In addition, genetic vulnerability also plays a role in alcoholism and, perhaps, in alcoholic medical disorders.

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