2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors
- PMID: 9016321
- DOI: 10.1021/jm960637m
2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors
Similar articles
-
S 18126 ([2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl]), a potent, selective and competitive antagonist at dopamine D4 receptors: an in vitro and in vivo comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2, 3b]pyridine) and raclopride.J Pharmacol Exp Ther. 1998 Oct;287(1):167-86. J Pharmacol Exp Ther. 1998. PMID: 9765336
-
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.J Med Chem. 1996 Jun 21;39(13):2435-7. doi: 10.1021/jm960084f. J Med Chem. 1996. PMID: 8691438 No abstract available.
-
L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.J Pharmacol Exp Ther. 1997 Dec;283(3):1256-63. J Pharmacol Exp Ther. 1997. PMID: 9400001
-
[Functional role of dopamine D4 receptor in schizophrenia].Nihon Shinkei Seishin Yakurigaku Zasshi. 2004 Feb;24(1):13-20. Nihon Shinkei Seishin Yakurigaku Zasshi. 2004. PMID: 15027326 Review. Japanese.
-
Dopamine D3 and D4 receptor antagonists in the treatment of schizophrenia.Curr Opin Investig Drugs. 2002 Jan;3(1):101-5. Curr Opin Investig Drugs. 2002. PMID: 12054059 Review.
Cited by
-
Neuropharmacological profile of an atypical antipsychotic, NRA0562.CNS Drug Rev. 2003 Winter;9(4):375-88. doi: 10.1111/j.1527-3458.2003.tb00261.x. CNS Drug Rev. 2003. PMID: 14647530 Free PMC article. Review.
-
How do the atypical antipsychotics work?J Psychiatry Neurosci. 2001 Nov;26(5):385-94. J Psychiatry Neurosci. 2001. PMID: 11762206 Free PMC article. Review.
-
A pharmacophore model for dopamine D4 receptor antagonists.J Comput Aided Mol Des. 2000 Nov;14(8):769-86. doi: 10.1023/a:1008198026843. J Comput Aided Mol Des. 2000. PMID: 11131969
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information