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Case Reports
. 1997 Feb;29(2):287-9.
doi: 10.1016/s0196-0644(97)70283-x.

Serotonin syndrome associated with nefazodone and paroxetine

L John  1 , M M Perreault, T Tao, P G Blew
Affiliations
Case Reports

Serotonin syndrome associated with nefazodone and paroxetine

L John et al. Ann Emerg Med. 1997 Feb.

Abstract

A 51-year-old woman was brought to the emergency department unresponsive, hyponatremic, and diaphoretic, with muscle rigidity. Her condition improved dramatically after supportive treatment and dantrolene. The patient had received nefazodone for 6 months, but the drug had been discontinued 2 days before admission after a tapering period. One day before admission, paroxetine 20 mg/day was started. A repeat challenge with paroxetine 7 days after discontinuation of nefazodone did not result in recurrence of the patient's symptoms. We believe this to be the first report of serotonin syndrome associated with nefazodone and paroxetine.

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Comment in

  • Toxic effects of nefazodone.
    Brazelton T, Blanc PD, Olson KR. Brazelton T, et al. Ann Emerg Med. 1997 Oct;30(4):550-1. doi: 10.1016/s0196-0644(97)70022-2. Ann Emerg Med. 1997. PMID: 9326873 No abstract available.
  • Toxic effects of nefazodone.
    Peak DA. Peak DA. Ann Emerg Med. 1997 Oct;30(4):551. Ann Emerg Med. 1997. PMID: 9326874 No abstract available.

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