doi: 10.1016/0301-4622(77)80006-9.
Theory of the delocalized binding of Mg(II) to DNA: preliminary analysis for low binding levels
- PMID: 901905
- DOI: 10.1016/0301-4622(77)80006-9
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Theory of the delocalized binding of Mg(II) to DNA: preliminary analysis for low binding levels
Biophys Chem.
1977 Sep.
Abstract
A simple theoretical equation for the binding of Mg2+ to DNA in the presence of excess 1:1 salt is derived from a model that does not specify discrete binding sites but rather allows the associated metal ions to move freely near the surface of the DNA polyion. Use of a numerical value for the free volume, determined uniquely, in a separate communication, by a free energy minimization, leads to predicted values for the Mg2+ binding constant that are in essential agreement with measured values taken from the literature.
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