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. 1977 Sep;5(5):423-6.

In vivo synchronization of haemopoietic stem cells with hydroxyurea

G Hodgson, N Blackett
  • PMID: 902705

In vivo synchronization of haemopoietic stem cells with hydroxyurea

G Hodgson et al. Exp Hematol. 1977 Sep.

Abstract

Four injections of hydroxyurea 1 mg/g body weight, given to normal mice 31, 24, 10 and 7 h before sampling bone marrow, reduced CFU-S content of femoral marrow to 30% of normal in Balb/c female and to 10% of normal in C57 B1 male mice. Over 80% of the surviving CFU-S were in the S phase of cycle, as judged from their sensitivity to killing by hydroxyurea or ARA-C.

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