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. 1997 Feb 21;275(5303):1122-6.
doi: 10.1126/science.275.5303.1122.

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

A M Chinnaiyan  1 , K O'Rourke, B R Lane, V M Dixit
Affiliations

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

A M Chinnaiyan et al. Science. .

Abstract

Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-xL (a member of the Bcl-2 family of cell death regulators) were both found to interact with and inhibit the function of CED-4. In addition, analysis revealed that CED-4 can simultaneously interact with CED-3 and its mammalian counterparts interleukin-1beta-converting enzyme (ICE) and FLICE. Thus, CED-4 plays a central role in the cell death pathway, biochemically linking CED-9 and the Bcl-2 family to CED-3 and the ICE family of pro-apoptotic cysteine proteases.

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Comment in

  • Controlling cell death.
    Golstein P. Golstein P. Science. 1997 Feb 21;275(5303):1081-2. doi: 10.1126/science.275.5303.1081. Science. 1997. PMID: 9054009 No abstract available.

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