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. 1997 Feb 21;275(5303):1129-32.
doi: 10.1126/science.275.5303.1129.

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

J Yang  1 , X Liu, K Bhalla, C N Kim, A M Ibrado, J Cai, T I Peng, D P Jones, X Wang
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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

J Yang et al. Science. .

Abstract

Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria.

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Comment in

  • Controlling cell death.
    Golstein P. Golstein P. Science. 1997 Feb 21;275(5303):1081-2. doi: 10.1126/science.275.5303.1081. Science. 1997. PMID: 9054009 No abstract available.

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