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Review
. 1997 Feb;7(1):3-9.
doi: 10.1016/s0959-440x(97)80002-4.

Nucleation mechanisms in protein folding

A R Fersht  1
Affiliations
Review

Nucleation mechanisms in protein folding

A R Fersht. Curr Opin Struct Biol. 1997 Feb.

Abstract

Experiment and theory are converging on the importance of nucleation mechanisms in protein folding. These mechanisms do not use classic nuclei, which are well formed elements of structure present in ground states, but they use diffuse, extended regions, which are observed in transition states.

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