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. 1997 Mar;71(3):2562-6.
doi: 10.1128/JVI.71.3.2562-2566.1997.

Mapping and characterization of the origin of DNA replication of porcine circovirus

A Mankertz  1 , F Persson, J Mankertz, G Blaess, H J Buhk
Affiliations

Mapping and characterization of the origin of DNA replication of porcine circovirus

A Mankertz et al. J Virol. 1997 Mar.

Abstract

The origin of DNA replication of porcine circovirus (PCV) was mapped to a 111-bp fragment. On top of a hairpin, a nonanucleotide (TAGTATTAC) homologous to nonanucleotides of other viruses was identified. Mutation of this element abolishes replication. PCV may be related to a virus family characterized by single-stranded circular DNA genomes, rolling-circle replication, and homology of their rep proteins.

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