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. 1997 Jan;67(1):31-4.
doi: 10.1111/j.1445-2197.1997.tb01890.x.

37 kBq 14C-urea breath test and gastric biopsy analyses of H. pylori infection

R A Allardyce  1 , B A Chapman, A B Tie, M J Burt, K J Yeo, J I Keenan, P F Bagshaw
Affiliations

37 kBq 14C-urea breath test and gastric biopsy analyses of H. pylori infection

R A Allardyce et al. Aust N Z J Surg. 1997 Jan.

Abstract

Background: The treatment of H. pylori-associated gastroduodenal disease is increasingly aimed at bacterial eradication which requires follow-up assessment of therapeutic effectiveness and re-infection. A simplified 37 kBq 14C-urea breath test for H. pylori infection has been developed.

Methods: The 37 kBq 14C-urea breath test was compared with biopsy urease (CLO) and histological analyses of gastric-biopsies obtained from 63 patients undergoing endoscopy.

Results: The 30-min breath test correlated closely with biopsy findings, had a sensitivity of 100%, a specificity of 95% and a positive predictive value of 92%.

Conclusions: The simplified, low-dose, 14C-urea breath test is a convenient, low-cost, transportable means of facilitating the management of H. pylori-associated diseases.

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