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Case Reports
. 1996;15(5):663-5.
doi: 10.1016/0750-7658(96)82131-9.

[Serotonin syndrome in acute poisoning with antidepressive agents]

[Article in French]
P Robert  1 , J M Senard, M Fabre, C Cabot, B Cathala
Affiliations
Case Reports

[Serotonin syndrome in acute poisoning with antidepressive agents]

[Article in French]
P Robert et al. Ann Fr Anesth Reanim. 1996.

Abstract

We report a case of severe serotonin syndrome after self-poisoning with two antidepressant drugs, paroxetine (a selective inhibitor of serotonin reuptake) and moclobemide (a reversible inhibitor of MAO-A). The serotonin syndrome is characterized by neuromuscular, behavioural, and autonomic changes. It occurs with the use of drugs able to increase serotonergic transmission in brain by acting on biosynthesis, reuptake, catabolism or release of serotonin. Treatment is symptomatic. The incidence of severe cases seems to have increased, probably due to the use of new antidepressant "specific" inhibitors of the serotonin reuptake.

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Comment in

  • [Fatal form of serotonin syndrome].
    Finge T, Malavialle C, Lambert J. Finge T, et al. Ann Fr Anesth Reanim. 1997;16(1):80-1. doi: 10.1016/s0750-7658(97)84292-x. Ann Fr Anesth Reanim. 1997. PMID: 9686110 French. No abstract available.

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