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. 1997 Jan;29(1):265-72.
doi: 10.1006/jmcc.1996.0271.

Increased expression of cardiac phosphatases in patients with end-stage heart failure

J Neumann  1 , T Eschenhagen, L R Jones, B Linck, W Schmitz, H Scholz, N Zimmermann
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Increased expression of cardiac phosphatases in patients with end-stage heart failure

J Neumann et al. J Mol Cell Cardiol. 1997 Jan.

Abstract

Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.

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