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. 1997 Jan;5(1):49-64.
doi: 10.1016/s0968-0896(96)00212-x.

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

T F Gallagher  1 , G L Seibel, S Kassis, J T Laydon, M J Blumenthal, J C Lee, D Lee, J C Boehm, S M Fier-Thompson, J W Abt, M E Soreson, J M Smietana, R F Hall, R S Garigipati, P E Bender, K F Erhard, A J Krog, G A Hofmann, P L Sheldrake, P C McDonnell, S Kumar, P R Young, J L Adams
Affiliations

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

T F Gallagher et al. Bioorg Med Chem. 1997 Jan.

Abstract

Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKC alpha and ERK kinase activity is observed.

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