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. 1997 Feb;24(1):1-8.
doi: 10.1111/j.1365-2370.1997.tb00001.x.

An investigation of polymorphism in the interleukin-10 gene promoter

D M Turner  1 , D M Williams, D Sankaran, M Lazarus, P J Sinnott, I V Hutchinson
Affiliations

An investigation of polymorphism in the interleukin-10 gene promoter

D M Turner et al. Eur J Immunogenet. 1997 Feb.

Abstract

Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

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