Abstract

PIP: Extraamniotic PGE2 and iv oxytocin in termination of midtrimester pregnancy and in the management of missed abortion and hydatiform mole are reported. 18 patients were divided into 2 groups: 1) 12 patients received an initial dose of 200 mcg of PGE2 and subsequent instillations of 100-200 mcg/hour. If abortion was not achieved in 12 hours, oxytocin was started. 2) 6 patients received an initial dose of 500 mcg of PGE2 and subsequent instillations with 500 mcg at 4, 6, and 8 hours, respectively. If abortion was not achieved by 6 hours, oxytocin was started. Abortion was achieved in all patients; 15 within 24 hours. Comcomitant administration of extraamniotic PGE2 and iv oxytocin was shown to be a safe and efficient way of inducing midtrimester abortion, missed abortion, and hydatiform mole. This methods is associated with minimum side effects and complications.