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. 1996 Nov;87(11):1097-101.
doi: 10.1111/j.1349-7006.1996.tb03116.x.

Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats

M Kitano  1 , Y Hirayama, J Tanuma, H Matsuuchi, Y Miura, T J Li, I Semba, H S Ozaki, T Kokubu, H Hatano, M Tada, Y Kobayashi, H Shisa
Affiliations

Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats

M Kitano et al. Jpn J Cancer Res. 1996 Nov.

Abstract

We analyzed the incidence of infiltrative mass-type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4-nitroquinoline 1-oxide solution for 180 days. The study included various crosses of susceptible Dark-Agouti rats (DA) and resistant Wistar/Furth rats (WF). DA showed a 93.6% incidence of IMTC measuring more than 5 mm in their largest diameter, while WF showed only a 4% incidence. Reciprocal F1 and F2 hybrids mated by DA and WF showed 47.5% and 45.8% incidences, respectively. Meanwhile, reciprocal backcrossed hybrids to DA and WF showed 73.7%, and 24.6% incidences, respectively. Segregation of the incidences suggests that there are two autosomal dominant genes, one linked to the susceptibility of DA and the other to the resistance of WF.

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References

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