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. 1996 Dec;87(12):1271-9.
doi: 10.1111/j.1349-7006.1996.tb03143.x.

Antitumor effect of Streptococcus pyogenes by inducing hydrogen peroxide production

Y Higuchi  1
Affiliations

Antitumor effect of Streptococcus pyogenes by inducing hydrogen peroxide production

Y Higuchi. Jpn J Cancer Res. 1996 Dec.

Abstract

The Su strain of Streptococcus pyogenes (S-coccus)-derived anticancer preparation, OK-432, which is immobilized by heating in the presence of penicillin G, is well known to have an immunopotentiating activity through activation of natural killer cells in vivo. In this study, a streptococcal anticancer preparation stronger than OK-432 was prepared. Live streptococci (S-cocci) of the Su strain were induced to acquire H202-producing ability by treatment with serum under aerobic conditions. The resulting preparation no longer possessed hemolytic activity, and was not viable. The serum-treated S-coccus preparation activated natural killer cells as well as OK-432 did, and had stronger antitumor activity than OK-432 did. These results suggest that the serum-treated S-coccus preparation would be a useful tool for chemotherapy, in addition to immunotherapy, for the treatment of cancer.

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References

    1. ) Higuchi , Y. , Kigoshi , S. and Shoin , S.Comparative experiments with hemolytic streptococcus and its anticancer preparations (OK‐431 and OK‐432) for their cytolytic activity . Jpn. J. Exp. Med. , 50 , 7 – 12 ( 1980. ). - PubMed
    1. ) Okamoto , H. , Minami , M. , Shoin , S. , Koshimura , S. and Shimizu , R.On the streptococcal preparation having potent anticancer activity . Jpn. J. Exp. Med. , 36 , 175 – 186 ( 1966. ). - PubMed
    1. ) Taketo , Y. and Taketo , A.Oncolytic activity in vitro of streptococci with special reference to cell bound hemolysin . J. Biochem. , 61 , 450 – 459 ( 1967. ). - PubMed
    1. ) Ginsburg , I. and Harris , T. N.Oxygen‐stable hemolysins of group A streptococci IV. Studies on the mechanisms oflysis by cell‐bound hemolysin of red blood cells and Ehrlich ascites tumor cells . J. Exp. Med. , 121 , 647 – 656 ( 1965. ). - PMC - PubMed
    1. ) Havas , H. F. , Donnelly , A. J. and Porreca , A. V.The cytolytic effects of hemolytic streptococci on ascites tumor cells . Cancer Res. , 23 , 700 – 706 ( 1963. ). - PubMed

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