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. 1997 Feb 14;40(4):622-4.
doi: 10.1021/jm9605039.

(+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent

K L Seley  1 , S W Schneller, D Rattendi, C J Bacchi
Affiliations

(+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent

K L Seley et al. J Med Chem. .

Abstract

The (+)-enantiomer of 7-deaza-5'-noraristeromycin (4) has been found to show IC50 values ranging from 0.16 to 5.3 microM against four strains of African trypanosomes, one Trypanosoma brucei brucei isolate, and several clinical isolates of Trypanosoma brucei rhodesiense (agent of east African sleeping sickness), including a multidrug resistant clone of one isolate. While this compound was originally designed to inhibit S-adenosyl-L-homocysteine hydrolase, it has been found to have no effect on this enzyme.

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