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. 1977 Sep 22;269(5626):307-11.
doi: 10.1038/269307a0.

Orientation of cell-surface antigens in the lipid bilayer of lymphocyte plasma membrane

F S Walsh, M J Crumpton

Orientation of cell-surface antigens in the lipid bilayer of lymphocyte plasma membrane

F S Walsh et al. Nature. .

Abstract

Human HLA-A, B, C and Ia antigens were labelled by lactoperoxidase-catalysed iodination of the inner surface of lymphocyte plasma membrane and thus are transmembrane proteins. In contrast, membrane-bound human IgM and mouse IgM, IgD and Thy-1 antigen were not labelled on the inner membrane surface.

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