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Review
. 1997 Jan;31(1-2):25-31.
doi: 10.1023/a:1005721027709.

Patterns of oncogene activation in human neuroblastoma cells

R Corvi  1 , L Savelyeva, M Schwab
Affiliations
Review

Patterns of oncogene activation in human neuroblastoma cells

R Corvi et al. J Neurooncol. 1997 Jan.

Abstract

Human neuroblastoma is the most frequent solid tumor in children. Recent studies suggest that a multiplicity of genomic alterations contributes to neuroblastoma, the most frequent and well studied being deletion of the short arm of chromosome 1 and amplification of N-MYC. We here present and discuss different patterns of oncogene activation including, amplification of N-MYC, duplication of N-MYC and amplification of MDM2.

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