Synthesis, characterisation and antifungal activity of some N-bridged heterocycles derived from 3-(3-bromo-4-methoxyphenyl)-4-amino-5-mercapto-1,2,4-triazole

Abstract

3-(3-Bromo-4-methoxyphenyl)-4-amino-5-mercapto-1,2,4-triazole was prepared starting from p-anisic acid. This new triazole was employed in the synthesis of some N-bridged heterocycles. All the newly synthesized compounds were characterized by analytical, IR, 1H-NMR and Mass Spectral studies. Some of the newly synthesized compounds were screened for their antifungal property against Thielaviopsis paradoxa, a fungus which is reported to cause stem-bleeding disease in coconut plants.