Review
doi: 10.1097/00062752-199704010-00006.
Killing mechanisms of cytotoxic lymphocytes
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- PMID: 9050377
- DOI: 10.1097/00062752-199704010-00006
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Review
Killing mechanisms of cytotoxic lymphocytes
Curr Opin Hematol.
1997 Jan.
Abstract
Killer lymphocytes are primary immune effectors of virus, certain bacteria, and tumor immunity and play a role in autoimmunity and transplant rejection. This article reviews progress in deciphering the mechanisms by which they kill target cells through induction of apoptosis by either the secretory, perforin/granzyme-based pathway or the nonsecretory pathway, (i.e., by triggering the cell-surface death receptor Fas (CD95) by the membrane-bound Fas ligand of the killer).
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