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Comment
. 1997 Mar 4;94(5):1615-8.
doi: 10.1073/pnas.94.5.1615.

Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing

D Unutmaz  1 , D R Littman
Affiliations
Comment

Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing

D Unutmaz et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Model for transmission of HIV-1. In this model of HIV pathogenesis, the infection is restricted to M-tropic viruses, which use CCR5 and CD4 for entry into target cells. Infection of macrophages/DC and memory T cell conjugates activates macrophage/DC, which in turn stimulate memory T cells. These conjugates allow productive HIV replication of M-tropic strains that eventually evolve into T-tropic or dual-tropic (strains using both coreceptors) viruses.
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