Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1996 Nov-Dec;46(6):1104-8.

[The effect of difenin, valproate and phenobarbital on the development of an epileptiform seizure attack in Krushinskiĭ-Molodkina rats]

[Article in Russian]
I B Fedotova, A F Semiokhina, D A Fless, G V Arkhipova
  • PMID: 9054163
Comparative Study

[The effect of difenin, valproate and phenobarbital on the development of an epileptiform seizure attack in Krushinskiĭ-Molodkina rats]

[Article in Russian]
I B Fedotova et al. Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 Nov-Dec.

Abstract

The anticonvulsant action of diphenin, sodium valproate, and pentobarbital was studied in Krushinskiĭ-Molodkina (KM) rats subjected to audiogenic seizures. The anticonvulsant effects of the drugs were different and dose-dependent. Valproate in a dose of 120 mg/kg completely eliminated the tonic phase of seizures. Given in a dose of 300 mg/kg it in 50% of cases prevented from the development of the initial seizure stage of motor excitation. The peculiarity of the pentobarbital action consisted in its ability to change the character of motor excitation during sound stimulation from the one-wave reaction for the two-wave.

PubMed Disclaimer