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. 1997 Mar;41(3):706-8.
doi: 10.1128/AAC.41.3.706.

Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis

T Luna  1 , R Mazzolla, G Romanò, E Blasi
Affiliations

Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis

T Luna et al. Antimicrob Agents Chemother. 1997 Mar.

Abstract

A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.

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