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. 1997 Feb;81(2):130-2.
doi: 10.1136/bjo.81.2.130.

Successful treatment of optic neuropathy in association with systemic lupus erythematosus using intravenous cyclophosphamide

J T Rosenbaum  1 , J Simpson, C M Neuwelt
Affiliations

Successful treatment of optic neuropathy in association with systemic lupus erythematosus using intravenous cyclophosphamide

J T Rosenbaum et al. Br J Ophthalmol. 1997 Feb.

Abstract

Background: Optic neuropathy is a rare manifestation of systemic lupus erythematosus (SLE). In a previous series most patients with optic neuropathy in association with SLE had a final visual acuity of 20/200 or less despite corticosteroid therapy.

Methods: Three patients (five affected eyes) with severe retrobulbar optic neuropathy in association with SLE were treated promptly with intravenous cyclophosphamide and corticosteroids.

Results: All patients recovered excellent visual acuity.

Conclusion: Although optic neuropathy in association with SLE might have several different aetiologies, intravenous cyclophosphamide should be strongly considered as a therapeutic alternative.

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Figures

Figure 1
Figure 1
The visual acuity is represented as a ratio such that 20/20 would be 1 and 20/200 is represented as 0.1. For simplicity acuities are given for the right eye only. The left eye followed a very similar course.
See this image and copyright information in PMC

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