Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997 Mar;19(2):153-7.
doi: 10.1002/(sici)1097-0347(199703)19:2<153::aid-hed12>3.0.co;2-e.

Giant cell tumor of the larynx: case report and review of the literature

J A Werner  1 , D Harms, A Beigel
Affiliations
Review

Giant cell tumor of the larynx: case report and review of the literature

J A Werner et al. Head Neck. 1997 Mar.

Abstract

Background: Primary manifestation of a giant cell tumor (GCT) in the larynx is exceedingly rare. Until now, only 17 cases have been reported in the literature. Characterization of a GCT can be difficult partly because of similarities with the giant cell subtype of malignant fibrous histiocytoma (MFH).

Methods: The case of a 35-year-old man with a laryngeal GCT is presented. The patient underwent laryngectomy and has been free of recurrence since then (90 months). The literature is reviewed, and previously reported cases are presented in a table and compared with the presented case. The difficulties in the differential diagnosis are discussed.

Conclusions: When a laryngeal GCT is diagnosed, further differential diagnostic considerations should follow. One of these considerations is the MFH, which displays considerably more cellular atypia than GCT. Because most cases of giant cell MFH are high-grade sarcomas, the distinction between GCT and MFH is necessary.

PubMed Disclaimer

LinkOut - more resources