Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Apr;71(4):2615-20.
doi: 10.1128/JVI.71.4.2615-2620.1997.

The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl

P Dupraz  1 , N Rebai, S J Klein, N Beaulieu, P Jolicoeur
Affiliations

The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl

P Dupraz et al. J Virol. 1997 Apr.

Abstract

The Pr60gag protein of the murine AIDS (MAIDS) defective virus promotes the proliferation of the infected target B cells and is responsible for inducing a severe immunodeficiency disease. Using the yeast two-hybrid system, we identified the SH3 domain of c-Abl as interacting with the proline-rich p12 domain of Pr60gag. The two proteins were shown to associate in vitro and in vivo in MAIDS virus-infected B cells. Overexpression of Pr60(gag) in these cells led to a detectable increase of the levels of c-Abl protein and to its translocation at the membrane. These results suggest that this viral protein serves as a docking site for signaling molecules and that c-Abl may be involved in the proliferation of infected B cells.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1975 May;72(5):1932-6 - PubMed
    1. Cell Growth Differ. 1996 Sep;7(9):1141-8 - PubMed
    1. J Virol. 1986 Mar;57(3):1182-6 - PubMed
    1. J Virol. 1986 Apr;58(1):96-106 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1985;50:643-50 - PubMed

Publication types

MeSH terms

LinkOut - more resources