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. 1997;75(6):822-8.
doi: 10.1038/bjc.1997.147.

Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata

A M Di Massimo  1 , M Di Loreto, A Pacilli, G Raucci, L D'Alatri, A Mele, A Bolognesi, L Polito, F Stirpe, R De Santis
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Free PMC article

Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata

A M Di Massimo et al. Br J Cancer. 1997.
Free PMC article

Abstract

The present paper describes two immunoconjugates consisting of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb), named Mint5, covalently linked to the type 1 ribosome-inactivating proteins (RIPs) ocymoidine (Ocy) and pyramidatine (Pyra) from Saponaria ocymoides and Vaccaria pyramidata respectively. Both antibody and toxins are shown to retain their respective biological properties upon chemical conjugation. The immunoconjugates exert specific inhibition of EGFR expressing target cell proliferation and protein synthesis in in vitro assays and also inhibit the growth of grafted human tumour cells in nude mice.

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References

    1. Cancer Res. 1989 Jul 1;49(13):3482-8 - PubMed
    1. J Natl Cancer Inst. 1993 Aug 18;85(16):1327-33 - PubMed
    1. Br J Cancer. 1991 Oct;64(4):624-30 - PubMed
    1. Cancer Invest. 1991;9(5):553-62 - PubMed
    1. Prog Growth Factor Res. 1990;2(4):223-36 - PubMed

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