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Case Reports
. 1997 Mar;123(3):303-12.
doi: 10.1016/s0002-9394(14)70125-4.

Amniotic membrane transplantation for persistent epithelial defects with ulceration

S H Lee  1 , S C Tseng
Affiliations
Free article
Case Reports

Amniotic membrane transplantation for persistent epithelial defects with ulceration

S H Lee et al. Am J Ophthalmol. 1997 Mar.
Free article

Abstract

Purpose: To determine whether preserved human amniotic membrane can be used as an alternative substrate for treating persistent corneal epithelial defects with sterile ulceration.

Methods: Amniotic membrane transplantation was performed in 11 eyes of 11 consecutive patients with corneal ulcers of different causes that had persisted for a mean +/- SD of 17.5 +/- 13.9 weeks.

Results: Ten patients healed in 3.9 +/- 2.3 weeks (P < .01) without recurrence for 9.0 +/- 5.9 months. One patient failed to heal because of preexisting corneal perforation pursuant to severe rheumatoid arthritis.

Conclusion: Amniotic membrane transplantation may be considered an alternative method for treating persistent epithelial defects and sterile ulceration that are refractory to conventional treatment and before considering treatment by conjunctival flaps or tarsorrhaphy.

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