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. 1997 Mar;48(3):658-62.
doi: 10.1212/wnl.48.3.658.

Low-dose clozapine improves dyskinesias in Parkinson's disease

F Durif  1 , M Vidailhet, F Assal, C Roche, A M Bonnet, Y Agid
Affiliations

Low-dose clozapine improves dyskinesias in Parkinson's disease

F Durif et al. Neurology. 1997 Mar.

Abstract

The severity of parkinsonian motor disability and dyskinesias was evaluated in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist apomorphine, before and after low-dose clozapine (50 mg) for 18 +/- 2 days. There was a significant 59% improvement (p < 0.05) of apomorphine-induced dyskinesias without aggravation of parkinsonian motor disability following clozapine treatment. The results suggest that low-dose clozapine, already shown to improve psychotic symptoms, may help to reduce severe levodopa-induced dyskinesias in parkinsonian patients.

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