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. 1997 Apr;9(2):168-73.
doi: 10.1016/s0955-0674(97)80059-2.

Lysophosphatidic acid: G-protein signalling and cellular responses

W H Moolenaar  1 , O Kranenburg, F R Postma, G C Zondag
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Lysophosphatidic acid: G-protein signalling and cellular responses

W H Moolenaar et al. Curr Opin Cell Biol. 1997 Apr.

Abstract

Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates a specific G protein coupled receptor to evoke multiple cellular responses. Recent work has identified two cDNAs encoding putative LPA receptors, various LPA-like agonists that act on distinct receptors, and new pathways that link the receptor(s) to such diverse events as Ras signalling, cytoskeletal remodelling and membrane depolarization.

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