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. 1997 Mar 20;386(6622):239-46.
doi: 10.1038/386239a0.

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

K Kaupmann  1 , K Huggel, J Heid, P J Flor, S Bischoff, S J Mickel, G McMaster, C Angst, H Bittiger, W Froestl, B Bettler
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Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

K Kaupmann et al. Nature. .

Abstract

GABA (gamma-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABA(A)/ GABA(c)) and metabotropic (GABA(B)) receptor systems. Here we report the cloning of GABA(B) receptors. Photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABA(B) receptor forms present in the vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate.

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  • The cloning of GABA(B) receptors.
    Bowery NG, Brown DA. Bowery NG, et al. Nature. 1997 Mar 20;386(6622):223-4. doi: 10.1038/386223a0. Nature. 1997. PMID: 9069276 No abstract available.

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