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. 1997 Mar;157(3):992-5.
doi: 10.1016/s0022-5347(01)65128-0.

Posterior urethral valves: long-term renal function consequences after transplantation

L Salomon  1 , E Fontaine, M F Gagnadoux, M Broyer, D Beurton
Affiliations

Posterior urethral valves: long-term renal function consequences after transplantation

L Salomon et al. J Urol. 1997 Mar.

Abstract

Purpose: We assessed the long-term efficacy of renal transplantation in children with posterior urethral valves.

Materials and methods: We retrospectively compared the outcomes of renal transplantation in 66 children with posterior urethral valves and 116 with malformation uropathies (controls).

Results: Graft survival in the posterior urethral valves and control groups was 69 and 72% at 5 years, and 54 and 50% at 10 years, respectively (not statistically significant). A statistically significant increase in serum creatinine was noted at 10 years in children with posterior urethral valves but not in controls (p < 0.05).

Conclusions: Renal transplantation in children with posterior urethral valves is not associated with a high rate of failure. However, long-term deterioration of graft function is likely related to lower urinary tract dysfunction.

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