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Case Reports
. 1997 Jan;20(1):24-8.
doi: 10.1007/BF03347968.

Subacute thyroiditis during interferon-alpha therapy for chronic hepatitis C

P Falaschi  1 , A Martocchia, R D'Urso, A Proietti
Affiliations
Case Reports

Subacute thyroiditis during interferon-alpha therapy for chronic hepatitis C

P Falaschi et al. J Endocrinol Invest. 1997 Jan.

Abstract

A 34-year-old woman with chronic hepatitis C received interferon-alpha (IFN-alpha) therapy. Her thyroid function was normal and thyroid autoantibodies were negative before treatment. Four months after the beginning of the therapy she presented a clinical course of thyroiditis with a transient thyrotoxicosis. The diagnosis of subacute thyroiditis was confirmed by laboratory, ultrasonography, radioiodine scanning and fine needle aspiration findings. Thyroid autoantibodies were persisting negative. She suspended IFN-alpha therapy and she started non steroidal anti-inflammatory agents and beta-blockers. Latent hypothyroidism subsequently developed, but L-thyroxine therapy resulted in a rapid normalization of thyroid function tests.

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