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. 1997 Mar;22(3):129-32.
doi: 10.1006/mpat.1996.0098.

Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

J R Canvin  1 , J C Paton, G J Boulnois, P W Andrew, T J Mitchell
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Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

J R Canvin et al. Microb Pathog. 1997 Mar.

Abstract

Pneumococci are described as alpha-haemolytic but under certain circumstances they produce zones of beta-haemolysis on blood-containing medium. This observation was investigated using wild type strains and a genetically-modified strain unable to produce the haemolytic toxin, pneumolysin. beta-haemolysis was produced by all pneumococci tested. It was not inhibited by anti-pneumolysin antibody but could be inactivated by cholesterol. These data confirm that pneumococci elaborate a second haemolysin, distinct from pneumolysin.

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