A murine model of pulmonary damage induced by lipopolysaccharide via intranasal instillation
- PMID: 9075771
- DOI: 10.1016/s0022-1759(96)00236-0
A murine model of pulmonary damage induced by lipopolysaccharide via intranasal instillation
Abstract
This study examines the intranasal instillation of lipopolysaccharide (LPS) into BALB/c mice causing acute pulmonary damage, due to neutrophil infiltration and sepsis. A dose response with LPS showed that an intranasal instillation of 167 microg/ml (10 microg/mouse) caused acute lung injury within 2-4 h and reached maximal damage at 24-48 h. We found the method of LPS administration for induction of acute pulmonary damage to be crucial. After 24 h post-LPS injection, a comparison showed a substantial increase in pulmonary damage with intranasal instillation of LPS. As for intravenous injection, it showed a baseline effect. This study indicates that LPS administered intranasally causes acute pulmonary damage, whereas with intravenous and intraperitoneal endotoxin administration a tissue-specific or similar degree of pulmonary injury may not develop.
Similar articles
-
Lipopolysaccharide-induced lung injury in mice. I. Concomitant evaluation of inflammatory cells and haemorrhagic lung damage.Pulm Pharmacol Ther. 2000;13(2):61-9. doi: 10.1006/pupt.2000.0231. Pulm Pharmacol Ther. 2000. PMID: 10799283
-
Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice.Inflammation. 2015;38(3):1103-12. doi: 10.1007/s10753-014-0076-y. Inflammation. 2015. PMID: 25526714
-
[Protective effects of bactericidal/permeability increasing protein simulated peptide on murine acute lung injury induced by lipopolysaccharide].Zhonghua Shao Shang Za Zhi. 2005 Apr;21(2):100-3. Zhonghua Shao Shang Za Zhi. 2005. PMID: 15938953 Chinese.
-
Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice.Int Immunopharmacol. 2014 Dec;23(2):400-6. doi: 10.1016/j.intimp.2014.07.011. Epub 2014 Jul 22. Int Immunopharmacol. 2014. PMID: 25063711
-
Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung.Br J Pharmacol. 1996 Apr;117(8):1792-6. doi: 10.1111/j.1476-5381.1996.tb15356.x. Br J Pharmacol. 1996. PMID: 8732293 Free PMC article.
Cited by
-
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages.Nat Commun. 2020 Aug 27;11(1):4311. doi: 10.1038/s41467-020-18088-2. Nat Commun. 2020. PMID: 32855420 Free PMC article.
-
Preventive effect of Hochu-ekki-to on lipopolysaccharide-induced acute lung injury in BALB/c mice.Lung. 2006 Nov-Dec;184(6):318-23. doi: 10.1007/s00408-006-0018-z. Epub 2006 Nov 3. Lung. 2006. PMID: 17086464 Free PMC article.
-
Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies.Part Fibre Toxicol. 2022 Jan 20;19(1):7. doi: 10.1186/s12989-022-00449-y. Part Fibre Toxicol. 2022. PMID: 35057792 Free PMC article.
-
Immunogenicity of intranasally administered meningococcal native outer membrane vesicles in mice.Infect Immun. 1999 Jan;67(1):113-9. doi: 10.1128/IAI.67.1.113-119.1999. Infect Immun. 1999. PMID: 9864204 Free PMC article.
-
NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway.Mediators Inflamm. 2016;2016:7349603. doi: 10.1155/2016/7349603. Epub 2016 Nov 9. Mediators Inflamm. 2016. PMID: 27956761 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials