Efficacy of herpesvirus of turkeys vaccine against challenge with Marek's disease tumor cells
- PMID: 907584
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Efficacy of herpesvirus of turkeys vaccine against challenge with Marek's disease tumor cells
Avian Dis.
1977 Jul-Sep.
Abstract
Tests were made of the effectiveness of herpesvirus of turkeys (HVT) vaccine in preventing tumorigenesis following challenge with a neoplastically transformed Marek's disease tumor cell line (MSB-1). HVT vaccine prevented tumors due to MSB-1 inoculation whereas 21.4% of unvaccinated controls had tumors. The results support, but do not prove, the theory that HVT acts through enhancement of cell-mediated immunity against MDV-transformed cells. The drawbacks of using MSB-1 cells in this experiment and the need for true Marek's transplantable tumor cells are discussed.
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