[Disorder of glycolytic redox in the liver in experimental burn disease]

Abstract

The authors present the results of studies of the intensity of glycolytic oxidoreduction in the rat liver 3, 6, 12 and 24 days after the reproduction of experimental burn disease. This disease proved to lead to reduction of the glyceral-phosphate dehydrogenase activity and to decrease of 3-phosphoglyceric acid formation in the burned animals' liver, mostly expressed during burn toxemia (the 6th day). The limiting factor of the course of this reaction after the burn was the lack of NAD in the cell. Abnormality of the course of the investigated reaction was one of the reasons for reduced intensity during the glycolytic way of carbohydrate decay as a whole and for decrease of the energetic role of glucose in burn disease.