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. 1977 Aug;60(4):555-8.
doi: 10.1111/j.1476-5381.1977.tb07534.x.

Ligated renal pedicles and duration of action of neostigmine and pyridostigmine

R D Miller, L Roderick

Ligated renal pedicles and duration of action of neostigmine and pyridostigmine

R D Miller et al. Br J Pharmacol. 1977 Aug.

Abstract

1. The duration of neostigmine or pyridostigmine antagonism of a (+)-tubocurarine (Tc) neuromuscular blockade was determined in the cat anterior tibialis-peroneal nerve preparation with and without ligated renal pedicles. 2. The infusion rate of Tc required to maintain a 90% depression of twitch tension was reduced from 8.8 +/- 1.4 (s.e.) to 3.4 +/- 0.6 mugkg-1 min-1 by renal pedicle ligation. 3. Renal pedicle ligation resulted in an increased duration of antagonism of Tc by both neostigmine and pyridostigmine.

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References

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