Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997 Mar;18(3):115-20.
doi: 10.1016/s0167-5699(97)01005-0.

The function of costimulatory molecules and the development of IL-4-producing T cells

W C Gause  1 , M J Halvorson, P Lu, R Greenwald, P Linsley, J F Urban, F D Finkelman
Affiliations
Review

The function of costimulatory molecules and the development of IL-4-producing T cells

W C Gause et al. Immunol Today. 1997 Mar.

Abstract

The development of IL-4-producing effector T cells during a type 2 immune response requires signaling through B7 ligands, but probably not CD40 ligands. Here, William Gause and colleagues review the still controversial role of CD28 and CTLA-4 on T cells, and B7-1 and B7-2 on antigen-presenting cells, and provide a model to incorporate recent findings.

PubMed Disclaimer

Publication types

LinkOut - more resources