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Review
. 1997 Mar;18(3):127-35.
doi: 10.1016/s0167-5699(97)01007-4.

Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies

Y M Deo  1 , R F Graziano, R Repp, J G van de Winkel
Affiliations
Review

Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies

Y M Deo et al. Immunol Today. 1997 Mar.

Abstract

Fc receptors for IgG (Fc gamma Rs) can trigger the inflammatory, cytotoxic and hypersensitivity functions of immune effector cells. Activation or deactivation of effector cells via Fc gamma Rs can be exploited to develop novel therapies for cancer, infectious diseases and autoimmune disorders. Initial results of clinical trials for several Fc gamma R-directed immunotherapies show the potential promise of this approach.

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