Induction of hepatic aryl hydrocarbon hydroxylase in C57BL mice by ionizing radiation
- PMID: 908021
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Induction of hepatic aryl hydrocarbon hydroxylase in C57BL mice by ionizing radiation
Cancer Res.
1977 Oct.
Abstract
Inbred strains of C57BL mice were exposed to either 100, 500, or 1000 rads of whole-body irradiation. Another group of mice were given injections of 3-methylcholanthrene only, and a control group had no treatment. Forty-eight hr after treatment, the animals were killed and hepatic aryl hydrocarbon hydroxylase (AHH) activity was measured by spectrophotofluorometer. A comparison of hepatic AHH activity in treated and nontreated groups of mice showed that each treated group had a significantly increased AHH induction compared with the control group. Although radiation appeared to have a dose-related effect on AHH induction, the increase with dose level was not statistically significant.
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